About SEPHIENCE
What is SEPHIENCE?
SEPHIENCE is a prescription medicine used along with a phenylalanine (Phe)
-restricted diet to lower the amount of Phe in the blood in adults and children
1 month of age and older with phenylketonuria (PKU). It contains sepiapterin,
which your body converts into tetrahydrobiopterin (BH4)—a key molecule
that supports the enzyme that breaks down Phe and reduces its buildup.
Here are some of the benefits that may be possible with SEPHIENCE
Flexible once-daily dosing
Proven safety
profile
Shown to reduce Phe levels across all ages, from children to adults
Support and resources available at every step
How it works
In people with PKU, the body can’t break down Phe the way it should, causing it to build up in the blood and brain. Over time, high Phe levels can affect how you think, feel, and function. SEPHIENCE is thought to work by providing sepiapterin—a compound your body converts into BH4, a natural helper that supports the phenylalanine hydroxylase (PAH) enzyme in breaking down Phe.
Taken as an oral powder
Converts to natural BH4, which aids Phe breakdown
Reduces Phe levels to
help manage PKU
SEPHIENCE doesn’t just add BH4—it helps your body make its own, supporting your natural process.
Want to see how SEPHIENCE is taken?
See dosing information, mixing options, and tips for building SEPHIENCE into your routine.